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The Impact of Pumpkin Seed Extracts on the Histology of the Hypothalamus and Testosterone Level of Alloxan Induced Diabetic Male Rats

  • Udi Onoriode Andrew
  • Okoro Ogheneyebrorue Godswill
  • Lucky Omamuzo Ogagayere
  • Ahama Endurance Efe
  • Enaohwo Taniyowho Mamerhi
  • Igben Vincent-Junior Onoriode
  • Chris-Ozokor LiLian Ebeye
  • Ogba Grace Oreva

Asian Journal of Medicine and Health, Page 1-7
DOI: 10.9734/ajmah/2022/v20i12763
Published: 9 November 2022

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Abstract


Objective: Epidemiologic studies and randomized clinical trials demonstrate that type 2 diabetes can be substantially avoided by making dietary and lifestyle changes rather than relying heavily on medications. This study evaluates the ameliorating effect(s) of Telfairia occidentalis seed administration on the histology of the Hypothalamus and testosterone level in normal and Alloxan-induced diabetes in Wistar rats.


Methods: Twenty male Wistar rats, weighing between 120-180 g, were divided into five groups of 4 rats each. Groups 1 and 2 representing Normal Control (NC) and Diabetic Control (DC) received only feed and water. Group 3 normal rats received 300 mg/kg Telfairia occidentalis seed extract; groups 4 and 5 received 50 mg/kg of Metformin and 300 mg/kg of Telfairia occidentalis seed extract respectively.


Results: The result revealed that the administration of Telfairia occidentalis seed extract moderately increased the body weight (16.76±1.75%) significantly at (P<0.05) when compared to normal control (14.06±2.93%) and diabetes significant decrease (-27.68±1.92%) body weight when compared to metformin-treated (-6.11±1.85%) and extract (-5.33±2.18%). The levels of FBG with the extract (60.70±4.88%) and metformin (61.24±6.19%) significantly decreased at (p<0.05) when compared to diabetic control (-64.78±12.51%).The FSH and LH level significantly increased at (p<0.05). Histological changes were also seen in animals of the treated groups.


Conclusion: It is evident that Telfairia occidentalis seed extract contains anti-hyperglycemic agents capable of lowering blood glucose levels.


Keywords:
  • Pumpkin seed
  • hypothalamus
  • testosterone
  • diabetic
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How to Cite

Andrew, U. O., Godswill, O. O., Ogagayere, L. O., Efe, A. E., Mamerhi, E. T., Onoriode, I. V.-J., Ebeye, C.-O. L., & Oreva, O. G. (2022). The Impact of Pumpkin Seed Extracts on the Histology of the Hypothalamus and Testosterone Level of Alloxan Induced Diabetic Male Rats. Asian Journal of Medicine and Health, 20(12), 1-7. https://doi.org/10.9734/ajmah/2022/v20i12763
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References

Badifu GI, Akpapunan MA, Mgbemere VM. The fate of beta-carotene in processed leaves of fluted pumpkin, a popular vegetable in Nigerian diet plant foods. Hum. Nutri. 1995;48:141-147.

Balkau B. The DECODE study, Diabetes epidemiology: Collaborative analysis of diagnostic criteria in Europe. Diabetes Metab. 2000;26:282-286.

Edem DO, Ekanem IS,Ebong PE. Effect of aqueous extracts of alligator pear seed (Persea americana Mill) on blood glucose and histopathology of pancreas in alloxan-induced diabetic rats. Pak J Pharm Sci. 2009;22(3):272-276.

Dhasarathan P, Hemalatha N, Theriappan P, Ranjitsingh A. Antibacterial activities of extracts and their fractions of leaves of Tridax procumbens Linn. AJBS. 2011;1: 13-17.

Amos AF, Carty MC, Zimmet P. The rising global burden of diabetes and its complications: Estimates and projections to the year. Diabet Med. 2010;14:1e85.

Zibula SM, Ojewole JA. Hypoglycemic effects of Hypoxis hemerocallidea corm ‘African potato' methanolic extract in rats. Medical Journal of Islamic Academy of Sciences. 2000;13:75-78.

Syamsudin I, Winarno H. The effect of inai (Lawsonia inermis) leaves extract on blood glucose level: An experimental study. Research Journal of Pharmacology. 2008; 2(2):20-23.

Deore SL, Khadabadi SS, Daulatkar VD, Deokate UA, Farooqui IU. Evaluation of hypoglycemic and antidiabetic activity of bark of Butea monosperma. Phcog Mag. 2008;4:134-138.

Ignacimuthu S, Ayyanar M, Sivaraman SK. Ethnobotanical investigations among tribes in Madurai district of Tamil Nadu (India). Journal of Ethnobiology and Ethnomedicine. 2006;2:1-7.

Kochhar A, Nagi M. Effect of supplementation of traditional medicinal plants on blood glucose in non– insulin-dependent diabetics: A pilot study. Journal of Medicinal Food. 2008;8:545-549.

John CO, Lilian EC, Mamerhi TE, Francisca OO, Vera AO, Onoriode AU. Antioxidative properties of Ocimum gratissimum alters lead acetate induced oxidative damage in lymphoid tissues and hematological parameters of adult wistar rats. Journal of Toxicological Report. 2021; 215-222.

Udi OA, Oyem JC, Ebeye OA, Chris-Ozoko LE, Igbigbi SI, Olannye DU. The effects of aquous extract of Ocimum gratissimum on the cerebellum of male wistar rats challenge by lead acetate. Clinical Nutrition Open Science. 2022;44: 28-41.
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