Aflatoxins, Dairy Products Contamination in the Incidence and Development of Diseases in Children Population – A Short Systematic Review
Francisco José Mendes Dos Reis
Postgraduate Program in Health and Development in the Midwest Region, University of Mato Grosso do Sul, Campo Grande, MS, Brazil, Toxicology Integrated Surveillance Center/ Health Department of Mato Grosso do Sul State, Brazil and Group of Spectroscopy and Bioinformatics Applied to Biodiversity and Health, School of Medicine, Postgraduate Program in Health and Development in the Midwest Region, Brazil.
Eliza Miranda Ramos *
Postgraduate Program in Health and Development in the Midwest Region, University of Mato Grosso do Sul, Campo Grande, MS, Brazil and Group of Spectroscopy and Bioinformatics Applied to Biodiversity and Health, School of Medicine, Postgraduate Program in Health and Development in the Midwest Region, Brazil.
Antonio Marcos Jacques Barbosa
Central Laboratory of Public Health of Mato Grosso do Sul State / Health Department of Mato Grosso do Sul State, Brazil.
Daniela Granja Arakaki
Group of Spectroscopy and Bioinformatics Applied to Biodiversity and Health, School of Medicine, Postgraduate Program in Health and Development in the Midwest Region, Brazil.
Valter Aragão Do Nascimento
Postgraduate Program in Health and Development in the Midwest Region, University of Mato Grosso do Sul, Campo Grande, MS, Brazil and Group of Spectroscopy and Bioinformatics Applied to Biodiversity and Health, School of Medicine, Postgraduate Program in Health and Development in the Midwest Region, Brazil.
*Author to whom correspondence should be addressed.
Abstract
Aims: This study aimed to characterize a profile according to a systematic review when addressing the acute effects and side effects on child health and the importance of preventive measures for controlling food in the presence of aflatoxins and mycotoxins.
Methods: The method used was a systematic review. We conducted a systematic review of the SCOPUS, PUBMED, COCHRANE databases to identify all potential publications between the years 2005 and 2018. At the same time, short and extended abstracts were excluded. The language of the studies was in English and Portuguese. After this process, the selected articles were examined and the data extracted for analysis were 05 articles.
Results: The initial search resulted in 289 randomized experimental articles. the presence of liver cancer is represented as the primary effect of chronic toxicity related to high dose intake in an ordinary matter. The aflatoxins B1 promotes the formation of hepatocellular carcinoma and it can occur with lower doses than the standard established of 30 µg/kg.
Conclusion: This systematic review shows the need for food control regarding aflatoxins contamination, especially food targeting children, once the health damages can occur in both acute and chronic exposures, bringing growth and development impairment due to immune system disorders and frequent infections.
Keywords: Aflatoxin, aflatoxicosis, mycotoxins, incidence, child