The Magnitude and Risk Factors of Acute Respiratory Distress Syndrome among Newborn Admitted To Neonatal Intensive Care Unit at Benghazi Medical Center
Asian Journal of Medicine and Health,
Background: Hyaline Membrane Disease (HMD)/Respiratory Distress Syndrome (RDS) is the most common lung condition affecting premature babies. The inadequate amount of surfactant causes alveoli to collapse when the baby breathes out. It is hard for your baby to re-inflate the collapsed alveoli when he breathes. The lack of surfactant and resulting inflammation is called. Hyaline Membrane Disease (HMD)/Respiratory Distress Syndrome (RDS).
Aim of the Study: To determine the magnitude of Hyaline membrane disease or respiratory distress syndrome and identify the risk factors and complication among newborn babies in neonatal intensive care unit at Benghazi medical center (BMC).
Materials and Methods: Case series study. The study was conducted during the period between March 2017 to March 2018 of HMD cases at Benghazi medical center. A convenient sample of 120 cases diagnosed as HMD. Studied variables include the following; gestational age, birth weight, gender, type of pregnancy and type of delivery also the data for mothers such as (diabetes mellitus, preeclampsia hypothyroidism, receiving of Dexamethasone injection and premature rupture of membrane). Also investigation and treatment and finally the outcomes of babies.
Statistical Methods: Data were analyzed with SPSS version 17, analysis of associations was made with application Chi - square test for categorical variables comparison, was applied for test of association P <0.25. P was considered statistically significant if ≤ 0.05.
Results: Female gender was predominant (52%). Most of cases of HMD were between 1000 -2000 kg. Among the 120 cases we have (15%) sever HMD and the majority of cases have moderate –to sever Hyaline membrane disease 39 (32.5%) whereas very sever HMD were observed in nearly 27% of cases. The risk factors were history of maternal preeclampsia, maternal diabetes mellitus, prematurity and low birth weight babies and neonatal sepsis, all these were found to be very common risk factors of HMD. Pearson chi-square test p value highly significant of female gender with complications of HMD. Our results observed more than half of babies were died.
Conclusion: The risk factors were history of maternal preeclampsia, maternal diabetes mellitus, prematurity and low birth weight babies and neonatal sepsis all these were found to be very common risk factors of HMD. Also we concluded that the cases had premature rupture of membrane, which identified as risk factors of hyaline membrane disease. Furthermore, we concluded that highly significant of female gender with complications of HMD, such as Pneumothorax, bronco pulmonary, dysplasia, intra ventricular hemorrhage and congenital heart diseases were common co- morbidities with respiratory distress syndrome, all these could be have an association with the development of hyaline membrane disease, finally we observed more than half of babies were died this is a warning sign for health services.
- Risk factors
- acute respiratory distress syndrome
- Intensive care unit
- neonatal health.
How to Cite
Amorim Melo ERA, de Barros Lima Filho A, Furtado Ferreira AC, de Sousa Carvalho G, da Conceição Brito JJ, et al. Prevalence of Meningitis in Patients with Late Neonatal Sepsis in a Reference Maternity. Ann Pediatr Child Health. 2018;6(3):1148.
Chandrakala R. Iyer, Naveen G, Suma HR, Kumarguru BN, Swetha K, Janakiraman. Clinical profile and outcome of neonates with suspected sepsis form a rural medical college hospital of South India. International Journal of Contemporary Pediatrics Iyer CR et al. Int J Contemp Pediatr. 2018;5(1):55-60.
Million Wesenu, Sudhir Kulkarni,Tafere Tilahun. Modeling Determinants of Time-To-Death in Premature Infants Admitted to Neonatal Intensive Care Unit in Jimma University Specialized Hospital Ann. Data. Sci. 2017;4(3):361–381.
Sudigdo Sastroasmoro. Risk Factors for the Development of Hyaline Membrane Disease in Preterm Infants. Paediatric Indonesia J. 1998;38:243-254.
WHO, Unicef, World Bank Group & united Nation. Report 2019. Levels & Trends in Child Mortality. Estimates developed by the UN Inter-agency Group for Child Mortality Estimation.
Bashir M. Ashour, Anwar Gassier, Yosef Shami, Jalal A. Bilal &, Ishag Adam. Neonatal out come in Misurata central Hospital – Libya. Journal of Science. 2014;4(2):87-89.
Berhe Weldearegawi, Yohannes Adama Melaku, Semaw Ferede Abera, Yemane Ashebir, Fisaha Haile, Afework Mulugeta et al. infant mortality and causes of infant deaths in rural Ethiopia: a population-based cohort of 3684 births. BMC Public Health. 2015;15(Article no. 770).
Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371:75–84.
National Heart, Lung, and Blood Institute Web site. What is respiratory distress syndrome? Accessed January 21, 2010. Available:http://www.nhlbi.nih.gov/health/dci/Diseases/rds/rds_all.html.
Robertson PA, Sniderman SH, Laros RK Jr, Cowan R, Heilbron D, Goldenberg RL, Iams JD, Creasy RK. Neonatal morbidity according to gestational age and birth weight from five tertiary care centers in the United States, 1983 through 1986. Am J Obstet Gynecol. 1992;166:1629 –1641.
Angus DC, Linde-Zwirble WT, Clermont G, Griffin MF, Clark RH. Epidemiology of neonatal respiratory failure in the United States: projections from California and New York. Am J Respir Crit Care Med. 2001; 164:1154–1160.
Jamie B. Warren& Jo Dee M. Anderson, Core Concepts: Respiratory Distress Syndrome Neo Reviews. 2009;10 (7):351- 361.
Halliday HL. Surfactants: past, present and future. J Perinatol. 2008;28:S47–S56.
Nkadi PO, Merritt TA, Pillers DA. An overview of pulmonary surfactant in the neonate: genetics, metabolism, and the role of surfactant in health and disease. Mol Genet Metab. 2009;97:95–101.
UCSF Children's Hospital .Intensive Care Nursery House Staff Manual. Respiratory distress syndrome. The Regent of the University of California. 2004;Chapter 9:79-84.
Melchor Sánchez-Mendiola,a Octavio C. Martínez-Natera, Nazarea Herrera-Maldonado,c Jesús Ortega-Arroyoc Estudio controlado del tratamiento de la enfermedad de membrana hialina del recién nacido pretérmino con surfactante pulmonary exógeno (porcino vs. bovino Gac Méd Méx. 2005;141( 4)
Advanced Neonatal Care Clinical & Therapeutic guideline.
Available:https:/ /ftp.ocg.msf.org/data/public/2b1f7b.php Version – Janvier 2015: 97-100
Orna Flidel-Rimon, Eric S. Shinwell. Respiratory Distress in the Term and Near-term Infant. Neo Reviews. 2005;6(6):290-289. Available:http://neoreviews.aappublications.org/ at McMaster University on July 27, 2012.
Steven W Ryan, Nicholas J Wild, Rosemary J Arthur, Ben N J Shaw. Prediction of chronic neonatal lung disease in very low birth weight neonates using clinical and radiological variables. Archives of Disease in Childhood. 1994;71 :F36-F39.
Available:http://fn.bmj.com/ on June 22, 2017 - Published by group.bmj.com
Reynolds E 0 R. Proc. r-oy. Soc. Med Journal. 1974;67:10.
Robert M. Kliegman. Respiratory distress syndrome. Nelson Textbook of pediatric. 20 th ed. Published by Elsevier. 2016;528-231.
David G. Sweet, Virgilio Carnielli, Gorm Greisen , Mikko Hallman Eren Ozek, Arjan te Pas et al. European Consensus Guidelines on the Management of Respiratory Distress Syndrome – 2019 Update Neonatology. 2019;115:432–450. Available: www.karger.com/neo
Clare A. Berry, Béla Suki, Graeme R. Polglase and J. Jane Pillow Variable ventilation enhances ventilation without exacerbating injury in preterm lambs with respiratory distress syndrome. Pediatric Research. 2012;72(4):384-391.
Anna Mihaylova, Stanislav Gueorguiev, Nikoleta Parahuleva, Emilia Karaslavova, Milena Sandeva, Elina Petkova-Gueorguieva et al. Frequency of hyaline membrane disease in preterm infants after prenatal coid prophylaxis Biomedical Research . 2018;29(6):1115- 1119.
Ceane Cunha Rios Lessa, Fernando Lamy Filho, Zeni Carvalho Lamy Antônio Augusto Moura da Silva, Maria Elizabeth Lopes Moreira Maria Auxiliadora de Souza Mendes Gomes. Prevalence and factors associated with surfactant use in Brazilian Neonatal Intensive Care Units: A multilevel analysis Ciência & Saúde Coletiva. 2018;23(9):3067-3076.
Joan Crane & St. John’s. Antenatal corticosteroids therapy for fetal maturation. Journal obtet Gynaecol Can. 2003;25 (1):45-8.
Kathleen Mayor-Lynn, Vı´ctor Hugo Gonza´lez-Quintero, Mary Jo O’Sullivan, Alan I. Hartstein &Sonia Roger & Madeline Tamayo. Comparison of early-onset neonatal sepsis caused by Escherichia coli and group B Streptococcus. American Journal of Obstetrics and Gynecology. 2005;192:1437–9.
Foad Al Magri, Abdellatif Amnaina, Omar El Shourbagy, and Yakut El Senosy, Neonatal Sepsis in Derna, Libya. Sebha MJ. 2009;8(2):63-68.
Meharban Singh, Ashok K. Deorari, Rajiv Aggarwal & Vinod K. Paul. Assisted ventilation for hyaline membrane disease. India Institute of Medical Sciences, New Delhi. Department of Pediatrics. 1995; 1268 -1274.
Stevens TP, Sinkin RA. Surfactant replacement therapy. Chest.2007;131: 1577–1582.
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