Maternal Nutrition and Fetal Programming of the Immune System: Epidemiological and Experimental Evidences
Siti Rohaiza Ahmad *
PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Jalan Tungku Link, BE1410, Brunei Darussalam.
*Author to whom correspondence should be addressed.
Abstract
Maternal nutrition will not only affects pregnancy outcomes (such as birth weight) but will also affect the state of the fetus in their adult life in terms of diseases occurrence and also immune system development. Inadequate nutrition particularly will have a negative impact on the proliferation of the various cell populations responsible for the immune functions as well as the accumulation of high concentrations of inflammatory components. Maternal nutrition affects immunity ‘programming' during the period of pre-natal and post-natal life. Over the last decade, epidemiological and experimental studies have helped to expedite more understanding of immunity ‘programming.' External exposures such as smoking, alcohol and drugs during fetal life have also shown to have an impact on immunity ‘programming.' In this review, the relationship between fetal programming and the immune system, such as effects on the various immune-cellular components through some evidence from epidemiological and experimental models will be discussed.
Keywords: Maternal nutrition, fetal programming, immune system, thymus