Metal Based α-glucosidase Inhibitors: Synthesis, Characterization and α-glucosidase Inhibition Activity of Transition Metal Complexes
I. P. Tripathi *
Department of Physical Sciences, Faculty of Science and Environment, Mahatma Gandhi Chitrakoot Gramodaya Vishwavidyalaya, Chitrakoot, Satna (M.P.), India
Aparna Dwivedi
Department of Physical Sciences, Faculty of Science and Environment, Mahatma Gandhi Chitrakoot Gramodaya Vishwavidyalaya, Chitrakoot, Satna (M.P.), India
Mahendra Mishra
Department of Physical Sciences, Faculty of Science and Environment, Mahatma Gandhi Chitrakoot Gramodaya Vishwavidyalaya, Chitrakoot, Satna (M.P.), India
*Author to whom correspondence should be addressed.
Abstract
Aims: The aim of current study to examine percentage inhibition of α-glucosidase by synthesized transition metal complexes of 1,6-diaminohexane.
Study Design: Current study is based on given experimental methodology.
Place and Duration of Study: Faculty of Science and Environment and Department of Physical Sciences, between June 2009 and July 2010.
Methodology: In current work we have synthesized metal complexes by various salts of Co(II), Cu(II), Ni(II) and Zn(II) with 1,6-diaminohexane and characterized by means of infrared and ultraviolet spectroscopy. α-glucosidase inhibition activity has performed by standardize method of Tripathi et al. and calculated their IC50 value.
Results: All synthesized metal complexes of 1,6-diaminohexane are showing α-glucosidase inhibition activity among them [Zn(dahe)3]2Cl having highest α-glucosidase inhibition activity with lowest IC50 value 1.196 mg/ml while [Ni(dahe)3]2Cl having lowest α-glucosidase inhibition activity with highest IC50 value 3.633 mg/ml.
Conclusion: α-glucosidase inhibitors are oral antidiabetic drugs, which are widely used as chemotherapeutic agents in the clinical treatment of diabetes and obesity. Synthetic α-glucosidase inhibitor may be effective for antidiabetic treatment and other disorders because it is easy to synthesize and also having a great possibility to inhibit α-glucosidase. We have performed in-vitro α-glucosidase inhibition activity of transition metal complexes of 1,6-diaminohexane; however, need further work to validate reliability.
Keywords: α-glucosidase, diabetes, chemotherapy, IC50 value