Effective pH-responsive Hydrazine-Modified Silica for Doxorubicin Delivery
Uyen Vy Vo
Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam and University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam and Industrial University of Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam
Tuong Vi Tran
Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam
Do Minh Thien Nguyen
Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam and International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 70000, Vietnam
Cuu Khoa Nguyen
Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam and University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam
Ngoc Tram Nguyen Thi
Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam and Tra Vinh University, No. 126, Nguyen Thien Thanh, Ward 5, Tra Vinh City, Tra Vinh Province 940000, Vietnam
Dai Hai Nguyen *
Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam and University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam
*Author to whom correspondence should be addressed.
Abstract
Aims: A type of pH-responsive porous nanosilica (PNS) for doxorubicin (DOX) delivery using Hydrazine was developed
Study Design: PNS was first prepared by a sol-gel method and then modified with Hydrazine via 3-glycidoxypropyltrimethoxysilane (GPTMS) as coupling agents, (PNS-GPTMS-Hydrazine) for loading of DOX (DOX/PNS-GPTMS-Hydrazine).
Place and Duration of Study: Department of Biomaterials & Bioengineering, Institute of Applied Materials Science, Vietnam Academy of Science and Technology, between February and June 2016.
Methodology: The obtained PNS-GPTMS-Hydrazine were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). Moreover, DOX loading and release behavior of PNS-GPTMS-Hydrazine were also evaluated.
Results: The PNS-GPTMS-Hydrazine was successfully synthesized with spherical shape and diameter range of 45-75 nm, which was a little larger than that of PNS-GPTMS of 35-65 nm. In addition, DOX was effectively encapsulated into PNS-GPTMS-Hydrazine nanoparticles, which was approximately 61.6%, and was slowly released up to 96 h in phosphate buffer saline (PBS, pH 7.4). Especially, the modified PNS was found to be rapidly release DOX under acidic environment (PBS, pH 5.5), indicating the pH-responsive property.
Conclusion: These results demonstrated that PNS-GPTMS-Hydrazine can be used as an effective and pH-responsive nanocarriers for DOX delivery.
Keywords: Porous nanosilica, hydrazine, 3-glycidoxypropyltrimethoxysilane, pH responsive, drug delivery system