Influence of Vitamin D Level on Diabetic Dyslipidemia
Mohamed Mashahit *
Internal Medicine Department, Faculty of Medicine, Fayoum University, Egypt
Alaa Elsayed
Internal Medicine Department, Faculty of Medicine, Fayoum University, Egypt
Hala Eltoukhy
Internal Medicine Department, Faculty of Medicine, Fayoum University, Egypt
*Author to whom correspondence should be addressed.
Abstract
Background: Vitamin D deficiency is greater than expected all over the world and it is linked to many health and disease conditions.
Aim of the Work: Our work aimed to study the relation between serum level of vitamin D 25( OH ) and lipid parameters.
Patients and Methods: This study included 176 participants 88 patients with type 2 diabetes mellitus and 88 clinically healthy volunteers age and sex matched persons with normal glycated hemoglobin as a control group and their age ranged from 30 to 60 years old. A full history and clinical examination were done for both patients and control group. Fasting samples (12hrs) for lipid parameters including total cholesterol, triglycerides, (HDL) and (LDH), serum 25 (OH) vitamin D level ,fasting blood sugar and 2 hour postprandial and (HbA1c).
Results: In this study 71 patients had vitamin D deficiency (80.7%) and 17(19.3%) patients had either vitamin D insufficiency or sufficiency. Compared to the control group which showed that 38 persons had deficient vitamin D (43.2%) and 50 (56.8%) had either vitamin D insufficiency or sufficiency, which demonstrate that there were high statistical significance difference between case and controls regarding to 25(OH)D with p-value <0.001. Although in diabetic patients with vitamin D deficiency, serum levels of total cholesterol, TG, and LDL were higher and HDL was lower compared to patients with vitamin D sufficiency, this association was statistically significant for serum level of TG (237.3 ± 120.9 vs. 186.3 ± 77.0), and HDL (33.5 ± 6.4 vs. 40.4 ± 13.2), with P=0.037 and 0.003, respectively. Also in the control group there was a statistically significant difference between participants with vitamin D deficiency when compared to those without regarding the mean values of triglycerides (257.4 ± 106.2 vs. 155.8 ± 108.9), and HDL (30.7 ± 10.1 vs. 44.3 ± 15.5), with P<0.0001. This study also revealed that there was a negative statistically significant correlation between vitamin D level and HbA1C (P=0.035) in diabetic group.
Conclusions: The results of the present study showed that serum concentrations of 25(OH) D were inversely associated with high TG and low HDL in both diabetics and control groups.
Keywords: Type 2 diabetes mellitus, lipid profile, vitamin D