Epidemiological Profile of End-Stage Renal Diseases in Riyadh, Saudi Arabia

Main Article Content

A. A. Alkhlaif
A. K. Alsuraimi
A. A. Bawazir

Abstract

Background/Aims: The Saudi Center for Organ Transplantation (SCOT) reported (2015) a total of 15,782 dialysis patients in Saudi Arabia. Out of these patients, 14,366 were treated via haemodialysis, whereas the remaining 1,416 underwent peritoneal dialysis.

Aims: This study aimed to assess common factors that led to ESRD among dialysis patients at King Abdullah’s Dialysis Care Project in Riyadh, Saudi Arabia.

Settings and Design: Cross-sectional hospital-based study was conducted in the period May-September 2017, in King Abdullah’s Dialysis Care Project in Riyadh, Saudi Arabia.

Methods and Materials: This was a retrospective registry-based study using secondary data from the registry at King Abdullah’s Dialysis Care Project in Riyadh, Saudi Arabia (South Center). Registered male and female adult dialysis patients at this centre were included in this study. Patient medical records including disease state, laboratory profiles, and medical complications were analyzed.

Statistical Analysis Used: Statistical Packages for Social Science (SPSS version 22) was used to analyse the data obtained. Various statistical analyses were conducted including means, frequencies, and regression analysis (odds ratio).A P-value of less than 0.05 was considered as significant in the study.

Results: A total of 300 patients (55% males and 45% females) were included in this study. The mean age of the sample was 53 years (±SD 16). The prevalence of overweight and obese ESRD patients were 26% and 30%, respectively. The high frequent co-morbidities among ESRD patients were hypertension (82%) followed by diabetes mellitus (57%). The results showed that out of 90% of dialysis complications, 10% were cases of infection.

Conclusions: ESRD is an important public health problem in Saudi Arabia with alarming in its annual rates. For a better understanding of the aetiology and specific risk factors provoking ESRD in Saudi Arabia, further studies need to be conducted.

Keywords:
ESRD, Riyadh, Saudi Arabia, risk factors, dialysis

Article Details

How to Cite
Alkhlaif, A. A., Alsuraimi, A. K., & Bawazir, A. A. (2020). Epidemiological Profile of End-Stage Renal Diseases in Riyadh, Saudi Arabia. Asian Journal of Medicine and Health, 18(7), 16-27. https://doi.org/10.9734/ajmah/2020/v18i730220
Section
Original Research Article

References

Ojo A. Addressing the global burden of chronic kidney disease through clinical and translational research. Transactions of the American Clinical and Climatological Association. 2014;125:229.

Arogundade FA, Barsoum RS. CKD prevention in Sub-Saharan Africa: A call for governmental, nongovernmental, and community support. American Journal of Kidney Diseases. 2008;51(3):515-523.

WHO. World health Statistics. Geneva, Switzerland: World Health Organization; 2012. ISBN 978 92 4 156444 1.

Al-Sayyari AA, Shaheen FA. End stage chronic kidney disease in Saudi Arabia. A rapidly changing scene. Saudi Medical Journal. 2011;32(4):339-346.

Hsu C-y, Iribarren C, McCulloch CE, Darbinian J, Go AS. Risk factors for end-stage renal disease: 25-year follow-up. Archives of Internal Medicine. 2009; 169(4):342-350.

Al-Rubeaan K, Youssef AM, Subhani SN, Ahmad NA, Al-Sharqawi AH, Al-Mutlaq HM, et al. Diabetic nephropathy and its risk factors in a society with a type 2 diabetes epidemic: A Saudi National Diabetes Registry-based study. PloS one. 2014;9(2).

Muntner P, Judd SE, Gao L, Gutiérrez OM, Rizk DV, McClellan W, et al. Cardiovascular risk factors in CKD associate with both ESRD and mortality. Journal of the American Society of Nephrology:ASN. 2013;2012070642.

Singh AK, Farag YM, Mittal BV, Subramanian KK, Reddy SRK, Acharya VN, et al. Epidemiology and risk factors of chronic kidney disease in India–results from the SEEK (Screening and Early Evaluation of Kidney Disease) study. BMC nephrology. 2013;14(1):114.

Bikbov B, Purcell CA, Levey AS, Smith M, Abdoli A, Abebe M, et al. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2020;395(10225):709-733.

GAS. Demographic survey 2016" Riyadh, SA: General Authority for Statistics; 2016. Available:https://www.stat.gov.sa/sites/default/files/en-demographic-research-2016_4.pdf

SCOT. Annual report: Saudi Center for Organ Transplantation. Riyadh. SA: Saudi Center for Organ Transplantation; 2014. Available:http://www.scot.gov.sa/Pages/Doc15.aspx?loc=219&loc2=118

SCOT Data. Dialysis in the Kingdom of Saudi Arabia. Saudi J Kidney Dis Transplant. 2015;26(4):839-848.

Available:http://www.sjkdt.org

Tuttle KR, Bakris GL, Bilous RW, Chiang JL, De Boer IH, Goldstein-Fuchs J, et al. Diabetic kidney disease: A report from an ADA Consensus Conference. American Journal of Kidney Diseases. 2014;64(4): 510-533.

Shaheen FA, Al-Khader AA. Epidemiology and causes of end stage renal disease (ESRD). Saudi Journal of Kidney Diseases and Transplantation. 2005;16(3):277.

Nagata M, Ninomiya T, Doi Y, Yonemoto K, Kubo M, Hata J, et al. Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: The Hisayama Study. Nephrology Dialysis Transplantation. 2010;25(8):2557-2564.

SCOT. Annual Report: Saudi Center for Organ Transplantation. Riyadh. SA: Saudi Center for Organ Transplantation; 2015. Available:http://www.scot.gov.sa/Pages/Doc15.aspx?loc=219&loc2=118

El Minshawy O, Ghabrah T, El Bassuoni E. End-stage renal disease in Tabuk Area, Saudi Arabia: An epidemiological study. Saudi Journal of Kidney Diseases and Transplantation. 2014;25(1):192.

Ghonemy TA, Farag SE, Soliman SA, El-Okely A, El-Hendy Y. Epidemiology and risk factors of chronic kidney disease in the El-Sharkia Governorate, Egypt. Saudi Journal of Kidney Diseases and Transplantation. 2016;27(1):111.

Al Ismaili F, Al Salmi I, Al Maimani Y, Metry AM, Al Marhoobi H, Hola A, et al. Epidemiological transition of end-stage kidney disease in Oman. Kidney International Reports. 2017;2(1):27-35.

USRDS. Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States" Bethesda. USA: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2011.

Yu M, Ryu D-R, Kim S-J, Choi K-B, Kang D-H. Clinical implication of metabolic syndrome on chronic kidney disease depends on gender and menopausal status: results from the Korean National Health and Nutrition Examination Survey. Nephrology Dialysis Transplantation. 2009;25(2):469-477.

Basheer KN. Major risk factors that lead to onset end-stage renal disease in northern west bank. An-Najah National University, Palastine; 2011.

Abd NMAE-f, El-raheem MMAE, Mawgod FIA, Aljabbab AA, Al Anazi BM. Epidemiology of Chronic Renal Failure in Arar, KSA, 1436. Journal of American Science. 2015;11(3s).

Sud M, Tangri N, Pintilie M, Levey AS, Naimark D. Risk of end-stage renal disease and death after cardiovascular events in chronic kidney disease; 2014. Circulation:CIRCULATIONAHA. 113.007106

El-Reshaid K, Al-Owaish R, Diab A. Hypertension in Kuwait: the past, present and future. Saudi Journal of Kidney Diseases and Transplantation. 1999;10(3): 357.

Peralta CA, Shlipak MG, Fan D, Ordoñez J, Lash JP, Chertow GM, et al. Risks for end-stage renal disease, cardiovascular events, and death in Hispanic versus non-Hispanic white adults with chronic kidney disease. Journal of the American Society of Nephrology. 2006;17(10):2892-2899.

Suleymanlar G, Yparmak M. Registry of Nephrology dialysis and transplantation in Turkey (Registry 2011). Istanbule Turkey Society of Nephrology; 2011.

Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Research and Clinical Practice. 2011;94(3):311-321.

Galperim B, Mattos AA, Stein AT, Schneider NC, Buriol A, Fonseca A, et al. Hepatitis C in hemodialysis: the contribution of injection drug use. The Brazilian Journal of Infectious Diseases. 2010;14(4):422-426.

Prakash S, Jain A, Sankhwar S, Usman K, Prasad N, Saha D, et al. Prevalence of hepatitis B & C viruses among patients on hemodialysis in Lucknow, Uttar Pradesh. Clinical Epidemiology and Global Health. 2014;2(1):19-23.

Duong CM, Olszyna DP, McLaws M-L. Hepatitis B and C virus infections among patients with end stage renal disease in a low-resourced hemodialysis center in Vietnam: A cross-sectional study. BMC public health. 2015;15(1):192.

Abbott KC, Glanton CW, Trespalacios FC, Oliver DK, Ortiz MI, Agodoa LY, et al. Body mass index, dialysis modality, and survival: Analysis of the United States renal data system dialysis morbidity and mortality wave II study. Kidney international. 2004;65(2):597-605.

Kramer HJ, Saranathan A, Luke A, Durazo-Arvizu RA, Guichan C, Hou S, et al. Increasing body mass index and obesity in the incident ESRD population. Journal of the American Society of Nephrology. 2006;17(5):1453-1459.

Al Saran K, Elsayed S, Molhem A, AlDrees A, AlZara H. Nutritional assessment of patients on hemodialysis in a large dialysis center. Saudi Journal of Kidney Diseases and Transplantation. 2011;22(4):675.

Kazancioğlu R. Risk factors for chronic kidney disease: An update. Kidney International Supplements. 2013;3(4):368.

Ganesh SK, Stack AG, Levin NW, Hulbert-Shearon T, Port FK. Association of elevated serum PO4, Ca× PO4 product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. Journal of the American Society of Nephrology. 2011;12(10):2131-2138.

Noori N, Kalantar-Zadeh K, Kovesdy CP, Bross R, Benner D, Kopple JD. Association of dietary phosphorus intake and phosphorus to protein ratio with mortality in hemodialysis patients. Clinical Journal of the American Society of Nephrology. 2010;5(4):683-692.

de Mutsert R, Grootendorst DC, Indemans F, Boeschoten EW, Krediet RT, Dekker FW, et al. Association between serum albumin and mortality in dialysis patients is partly explained by inflammation, and not by malnutrition. Journal of Renal Nutrition. 2009;19(2):127-135.

Guérin AP, London GM, Marchais SJ, Metivier F. Arterial stiffening and vascular calcifications in end‐stage renal disease. Nephrology Dialysis Transplantation. 2000;15(7):1014-1021.

Blacher J, Demuth K, Guerin AP, Safar ME, Moatti N, London GM. Influence of biochemical alterations on arterial stiffness in patients with end-stage renal disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 1998;18(4):535-541.

Raggi P, Boulay A, Chasan-Taber S, Amin N, Dillon M, Burke SK, et al. Cardiac calcification in adult hemodialysis patients: A link between end-stage renal disease and cardiovascular disease? Journal of the American College of Cardiology. 2002; 39(4):695-701.

Fukagawa M, Kazama JJ, Kurokawa K. Renal osteodystrophy and secondary hyperparathyroidism. Nephrology Dialysis Transplantation. 2002;17(suppl_10):2-5.

Moe SM. Current issues in the management of secondary hyper-parathyroidism and bone disease. Peritoneal dialysis international. 2001; 21(Suppl 3):S241-S246.

Bloembergen WE. Cardiac disease in chronic uremia: Epidemiology. Advances in Renal Replacement Therapy. 1997;4(3): 185-193.