Evaluating Serum Urea, Creatinine and Hemoglobin Level in Chronic Renal Failure of Pre and Post Dialysis at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Main Article Content

Kedir Endris Hassen
Addisu Gize Yeshanew

Abstract

Objective: The objective of this study was to evaluate serum urea, creatinine and hemoglobin level in chronic renal failure pre and post dialysis at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia.


Methodology: Cross sectional study design was conducted From February to May 2017 to all chronic kidney failure patients Ethio-Egyptian Nephrology unit in SPHMMC Addis Ababa Ethiopia. 5 ml of the blood will be obtained from each patient before and after dialysis. Each sample was divided in to two; half of the blood was placed in tubes containing anticoagulant (EDTA) and half in clot activator tubes. Clotted blood was centrifuge to separate serum and used for the estimation of creatinine and urea. Non-clotted blood samples were used for complete blood count and hemoglobin in blood Analyzer Sysmax KX-21. Percentages of reduction in urea and creatinine values were calculated using the values of blood samples withdrawn from each patient before and after each hemodialysis sessions.


Results: A total of 33 chronic kidney patients participated in this study. Out of this only 26 patients (78.79%) attend the dialysis unit for four months the rest either passed away or kidney transplantation done. The study population comprised 80.8% male and 19.2% female. Before the dialysis, 12 (46.2%) patients serum urea level was 101-122 mg/dl, however after dialysis, 14 (53.8%) patients had serum urea level were between 20 – 50.99 mg/dl and 11 (42.3%) patients had serum urea level were between 51 – 100 mg/dl. Most of the patients, (53.8%) undergoing hemodialysis serum creatinine level before dialysis were between 7.6 – 10.5 mg/dl. The majority of patients’ (42.3%), serum creatinine level after dialysis was between 3.0 – 3.92 mg/dl.  The majority (73.1%) of the patient hemoglobin level was between 7.0 – 11.0 mg/dl and 23.1% of the patients were between 11.1 – 14.0 mg/dl. Patients with chronic kidney disease have high serum urea and creatinine level before hemodialysis.


Conclusion: Hemodialysis decreases the burden of kidney in chronic kidney disease patients.

Keywords:
Urea, creatinine, hemoglobin, after and before hemodialysis.

Article Details

How to Cite
Hassen, K., & Yeshanew, A. (2019). Evaluating Serum Urea, Creatinine and Hemoglobin Level in Chronic Renal Failure of Pre and Post Dialysis at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. Asian Journal of Medicine and Health, 15(2), 1-10. https://doi.org/10.9734/ajmah/2019/v15i230117
Section
Original Research Article

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References

Guyton, Hall. Text book of medical physiology 12th ed. Saunders Elsevir Philadelpia. 2011;1091.

Amin N, Mahmood RT, Asad MJ, Zafar M, Raja AM. Evaluating urea and creatinine levels in chronic renal failure pre and post dialysis: A prospective study. JCVD; 2014.

Levey AS, Atkins R, Coresh J, Cohen EP, Collins AJ, Eckardt KU. Chronic kidney disease as a global public health problem: Approaches and initiatives -a position statement from Kidney Disease Improving Global Outcomes. Kidney International. 2007;72:247-259.

Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW. National kidney foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Annals of Internal Medicine. 2003;139(2):137–47.

Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P. Prevalence of chronic kidney disease in the United States. Journal of the American Medical Association. 2007;298(17):2038–47.

Bethesda MD. USRDS annual data report: atlas of chronic kidney disease and end-stage renal disease in the United States. 2009 .National Institute of Diabetes and Digestive and Kidney Diseases; 2009.

Couchoud C, Pozet N, Labeeuw M. Screening early renal failure: Cut-off values for serum creatinine as an indicator of renal impairment. Kidney International. 1999;55:1878–1884.

Santulli G, Trimarco B, Iaccarino G. G-protein-coupled receptor kinase 2 and hypertension: Molecular insights and pathophysiological mechanisms. High Blood Pressure Cardiovascular Prevention. 2013;20(1):5-12.

Unruh A, Kurella M, Brett T, Larive C, Rastogi A, James S. Impact of sleep quality on cardiovascular outcomes in hemodialysis patients: Results from the frequent hemodialysis network study. American Journal of Nephrology. 2011;33: 398-406.

Ethiopian Public Health Association (EPHA). Emerging Public Health Problems in Ethiopia: Chronic Non-Communicable Diseases; 2012.

John W. Stanifer, Bocheng Jing, Scott Tolan, Nicole Helmke, Romita Mukerjee, Saraladevi Naicker, Uptal Pate. The epidemiology of chronic kidney disease in sub-Saharan Africa: A systematic review and meta-analysis. Lancet Glob Health; 2014.

Suresh M, Mallikarjunareddy N, Sharan B, Singh M, Hari Krishna Bandi, Shravyakeerthi G, Chandrasekhar M. Hematological changes in chronic renal failure. International Journal of Scientific and Research Publications. 2012;2(9).

Noor ul Amin, Raja Tahir Mahmood, Javaid Asad M, Mudassar Zafar, Asad Mehmood Raja. Evaluating urea and creatinine levels in chronic renal failure pre and post dialysis. Journal of Cardiovascular Disease. 2014;2(2).

Molnar MZ, et al. Estimated glomerular filtration rate at reinitiation of dialysis and mortality in failed kidney transplant recipients. Nephrol Dial Transplant. 2012; 27:2913–2921.

Yazar H, Balci M, Basarali KM, Gocmen AY, Buyukbas S. The effects of dialysers on some blood biochemical parameters in hemodialysis patients. Afr. J. Pharm; 2011.

Fiseha, et al. Chronic kidney disease and under diagnosis of renal insufficiency among diabetic patients attending a hospital in Southern Ethiopia. BMC Nephrology; 2014.

KDIGO Clinical Practice Guideline for Acute Kidney Injury. 2012;2.

Nadia Khasawnah, Jaafar Abdulrahman Abu Abeeleh. Hematological and biochemical findings among Jordanian patient with end stage renal disease. E. Sc. J. 2015;11.

Entedhar Rifaat Sarhat, Nawal Abdullah Murtadha. Biochemical changes in chronic renal failure pre and post hemodialysis. Journal of Environmental Science and Engineering. 2016;5:190-195.

Furqan AL, et al. Evaluate some bio-chemical changes associated with chronic renal failure patients undergoing hemodi-alysis in al najaf al ashraf governorate. International Journal of Scientific and Research Publications. 2014;4(11).

Yang J, Lepper K, Robbins S. Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure. Circulation. 2006;113: 2713-2723.